133 research outputs found
In situ photo-crosslinked hydrogel promotes oral mucosal wound healing through sustained delivery of ginsenoside Rg1
Oral mucosal wounds exhibit an increased susceptibility to inflammation as a consequence of their direct exposure to a diverse range of microorganisms. This causes pain, slow healing, and other complications that interfere with patients’ daily activities like eating and speaking. Consequently, patients experience a significant decline in their overall quality of life. Therefore, the pursuit of novel treatment approaches is of great importance. In this study, ginsenoside Rg1, a natural active substance extracted from ginseng root, was chosen as a therapeutic agent. It was encapsulated in a screened photo-crosslinked hydrogel scaffold for the treatment of mucosal defects in the rat palate. The results demonstrated that Rg1-hydrogel possessed excellent physical and chemical properties, and that oral mucosa wounds treated with Rg1-hydrogel exhibited the greatest healing performance, as evidenced by more pronounced wound re-epithelialization, increased collagen deposition, and decreased inflammatory infiltration. Subsequent investigations in molecular biology confirmed that Rg1-hydrogel stimulated the secretion of repair-related factors and inhibited the secretion of inflammatory factors. This study demonstrated that the hydrogel containing ginsenoside Rg1 significantly promotes oral mucosal tissue healing in vivo. Based on the findings, it can be inferred that the Rg1-hydrogel has promising prospects for the therapeutic management of oral mucosal wounds
Hypermethylation of miR-338-3p and Impact of its Suppression on Cell Metastasis Through N-Cadherin Accumulation at the Cell -Cell Junction and Degradation of MMP in Gastric Cancer
Background/Aims: MicroRNAs (miRNAs) have been well studied in human carcinogenesis and cancer progression. Our previous study showed the down-regulation of miR-338-3p expression in human gastric cancer (GC). However, the reasons of this dysregulation remain largely unclear. Methods: Bisulfite sequence analysis was performed to explore the methylation status of the promoter region of miR-338-3p. Cell wound-healing and transwell assays were performed to examine the capacity of cell migration and cell interaction. A dual-luciferase reporter was used to validate the bioinformatics-predicted target gene of miR-338-3p. Western blotting, RNA interference, and immunofluorescence (IF) were used to evaluate the expression of MMPs and the location of N-cadherin to determine the mechanism underlying miR-338-3p-induced anti-tumor effects. Results: miR-338-3p was epigenetically silenced, and this loss of expression was significantly correlated with the Borrmann Stage in GC. Restoring miR-338-3p expression in BGC-823 cells inhibited cell migration and invasion. Moreover, Ras-related protein (Rab-14) and Hedgehog acyltransferase (Hhat) were identified as direct targets of miR-338-3p. Both enforced expression of miR-338-3p and small interfering RNA induced Rab14-mediated accumulation of N-cadherin in the cell -cell junctions or Hhat-associated matrix metalloproteinase (MMP) degradation, which may underline the metastasis defects caused by loss of miR-338-3p in GC. Conclusion: These data indicate that miR-338-3p functions as a tumor suppressor in GC, and that the hypermethylation status of its CpG island might be a novel potential strategy for treating GC
A universal programmable Gaussian Boson Sampler for drug discovery
Gaussian Boson Sampling (GBS) exhibits a unique ability to solve graph
problems, such as finding cliques in complex graphs. It is noteworthy that many
drug discovery tasks can be viewed as the clique-finding process, making them
potentially suitable for quantum computation. However, to perform these tasks
in their quantum-enhanced form, a large-scale quantum hardware with universal
programmability is essential, which is yet to be achieved even with the most
advanced GBS devices. Here, we construct a time-bin encoded GBS photonic
quantum processor that is universal, programmable, and software-scalable. Our
processor features freely adjustable squeezing parameters and can implement
arbitrary unitary operations with a programmable interferometer. Using our
processor, we have demonstrated the clique-finding task in a 32-node graph,
where we found the maximum weighted clique with approximately twice the
probability of success compared to classical sampling. Furthermore, a
multifunctional quantum pharmaceutical platform is developed. This GBS
processor is successfully used to execute two different drug discovery methods,
namely molecular docking and RNA folding prediction. Our work achieves the
state-of-the-art in GBS circuitry with its distinctive universal and
programmable architecture which advances GBS towards real-world applications.Comment: 10 pages, 5 figure
Observation of a charged charmoniumlike structure in at GeV
We study the process at a
center-of-mass energy of 4.26GeV using a 827pb data sample obtained with
the BESIII detector at the Beijing Electron Positron Collider. Based on a
partial reconstruction technique, the Born cross section is measured to be
pb. We observe a structure near the
threshold in the recoil mass spectrum, which we denote as the
. The measured mass and width of the structure are
MeV/c and MeV, respectively. Its
production ratio is determined to be . The first uncertainties
are statistical and the second are systematic.Comment: 7 pages, 4 figures, 1 table; version accepted to be published in PR
Search for the Lepton Flavor Violation Process at BESIII
We search for the lepton-flavor-violating decay of the into an
electron and a muon using events
collected with the BESIII detector at the BEPCII collider. Four candidate
events are found in the signal region, consistent with background expectations.
An upper limit on the branching fraction of (90% C.L.) is obtained
Search for Baryonic Decays of \psi(3770) and \psi(4040)
By analyzing data samples of 2.9 fb^{-1} collected at \sqrt s=3.773 GeV, 482
pb^{-1} collected at \sqrt s=4.009 GeV and 67 pb^{-1} collected at \sqrt
s=3.542, 3.554, 3.561, 3.600 and 3.650 GeV with the BESIII detector at the
BEPCII storage ring, we search for \psi(3770) and \psi(4040) decay to baryonic
final states, including \Lambda\bar\Lambda\pi^+\pi^-, \Lambda \bar\Lambda\pi^0,
\Lambda\bar\Lambda\eta, \Sigma^+ \bar\Sigma^-, \Sigma^0 \bar\Sigma^0,
\Xi^-\bar\Xi^+ and \Xi^0\bar\Xi^0 decays. None are observed, and upper limits
are set at the 90% confidence level.Comment: 9 pages, 3 figure
- …